Part 2 of the study will evaluate the antitumor activity of TSR-022, both as monotherapy and in combination with TSR-042 in participants with pre-specified tumor types. In the Phase 2 dose expansion portion, patients will be treated with doublet or triplet in the relapsed / refractory setting and earlier lines of therapy. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Participants in Cohort C will receive tucatinib. Chemotherapy drugs, such as leucovorin, fluorouracil, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. One exploratory single-agent atezolizumab (SAA) cohort may also be enrolled with CRPC subjects. Carcinomas of pituitary gland, thyroid gland parathyroid gland and adrenal cortex (closed to accrual) 27. Chordoma (closed to accrual 11 / 29 / 2018) 31. It is not yet known whether giving additional treatment with chemotherapy after surgery to patients who test positive for ctDNA and are at low risk for cancer recurrence would extend their time without disease compared to the usual approach (active surveillance). Antibodies that block PD-1 can potentially prevent PD-1 from shutting down the immune system, thus potentially allowing immune cells to recognize and destroy cancer cells. Location: 11 locations, This phase Ib / II trial studies the safety and best dose of cabozantinib-s-malate when given together with panitumumab in treating patients with colorectal cancer that has spread to other parts of the body or cannot be removed by surgery. Epithelial tumors of major salivary glands (closed to accrual 03 / 20 / 2018) 3. Malignant giant cell tumors 30. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 as a single agent (Part 1a); in combination with anti-programmed cell death protein-1 (PD-1) antibody, nivolumab (Part 1b); in combination with anti-PD-1 antibody, TSR-042 (Part 1c); in combination with TSR-042 and anti-lymphocyte-activation gene 3 (LAG-3) antibody, TSR-033 (Part 1d); in combination with TSR-042 in participants not previously treated with programmed death-ligand 1 [PD-(L)1] (Part 1e) and in combination with docetaxel (Part 1f). Bevacizumab may prevent the growth of new blood vessels that tumors need to grow. Colorectal Cancer Clinical Trials. provides estimated new cancer cases in 2019 by state. This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Location: 684 locations, This is a Phase 1 / 2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in patients with medullary thyroid cancer, RET-altered NSCLC and other RET-altered solid tumors. Trastuzumab is a form of “targeted therapy” because it works by attaching itself to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors. The clinical trials on this list are for colon cancer treatment. It’s all due to a Phase I clinical trial at MD Anderson, and a doctor’s willingness to experiment with a drug that was originally used only to treat advanced melanoma. Giving panitumumab may work better in treating patients with colorectal cancer than with the usual treatment of regorafenib or TAS-102. MetaPLASTIC carcinoma (of the breast) (closed to accrual) 37. Trastuzumab is a form of “targeted therapy” because it works by attaching itself to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors. Testing for ctDNA levels may help identify patients with colon cancer who benefit from receiving chemotherapy after surgery. Immunotherapy with monoclonal antibodies, such as panitumumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread Giving cabozantinib-s-malate with panitumumab may work better in treating patients with colorectal cancer. Tumor of unknown primary (Cancer of Unknown Primary; CuP) (closed to accrual 12 / 22 / 2017) 33. Location: 3 locations, This phase II trial studies how well TAS-102 and oxaliplatin work in treating patients with stage IV colon cancer. Small cell lung cancer is not eligible (temporarily closed to accrual 03 / 25 / 2020) 52. Purpose: To determine the safety and preliminary efficacy of selective combination targeted therapy for BRAF V600E-mutant metastatic colorectal cancer (mCRC) in the safety lead-in phase of the open-label, randomized, three-arm, phase III BEACON Colorectal Cancer trial ( ClinicalTrials.gov identifier: NCT02928224; European Union Clinical Trials … Vulvar cancer (temporarily closed to accrual) 36. In the first part of this study, participants enrolled into Cohort A and received both tucatinib and trastuzumab. The study is composed of a safety run-in and an exploratory part. PD-L1 amplified tumors 50. Giving vitamin D3 with chemotherapy and bevacizumab may work better in shrinking or stabilizing colorectal cancer. Location: 5 locations, This is a phase II, open-label, non-randomized study in subjects with histologically confirmed diagnosis of left-sided RAS WT advanced adenocarcinoma of the colon or rectum who have not received prior systemic therapy for metastatic disease. Location: 12 locations, Study of NGM120 in subjects with advanced solid tumors and pancreatic cancer. Angiosarcoma 51. It is the second leading cause of cancer death among men and women in the U.S, and an estimated one in 20 people will … The study will be conducted in 2 parts with Part 1 consisting of safety evaluation, pharmacokinetics (PK), and pharmacodynamics (PDy) of escalating doses of dostarlimab. The colon … Location: 28 locations, This is a multicenter Phase 1b, open-label study to assess safety, tolerability, preliminary efficacy, and pharmacokinetics (PK) of cabozantinib taken in combination with atezolizumab in subjects with multiple tumor types, including advanced urothelial carcinoma (UC) (including bladder, renal pelvis, ureter, urethra), renal cell carcinoma (RCC), castration-resistant prostate cancer (CRPC), non-small-cell lung cancer (NSCLC), triple negative breast cancer (TNBC), ovarian cancer (OC), endometrial cancer (EC), hepatocellular cancer (HCC), gastric cancer / gastroesophageal junction cancer / lower esophageal cancer (GC / GEJC / LEC), colorectal cancer (CRC), head and neck (H&N) cancer, and differentiated thyroid cancer (DTC). Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. Colorectal cancer … Bevacizumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Location: 15 locations, This is a Phase 1 / 2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in patients with medullary thyroid cancer, RET-altered NSCLC and other RET-altered solid tumors. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The clinical trials on this list are for colorectal cancer. This is genetic material unique to the cancer that may be present in the blood stream and can be identified through a ctDNA blood test. ctDNA are small pieces of genetic materials (DNA) that are shed by tumors into the blood. September 26, 2019. It is not yet known whether giving additional treatment with chemotherapy after surgery to patients who test positive for ctDNA and are at low risk for cancer recurrence would extend their time without disease compared to the usual approach (active surveillance). Studying vitamin D-bound sites and vitamin D-regulated genes may help doctors understand how cholecalciferol works in treating colorectal cancer and help doctors plan better treatment. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Location: 26 locations, This trial studies how well the drug tucatinib works when given with trastuzumab and when given by itself. Immunotherapy with monoclonal antibodies, such as pertuzumab and cetuximab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Endometrial carcinosarcoma (malignant mixed Mullerian tumors) (closed to accrual) 45. Location: 3 locations, The purpose of this phase 2 study is to evaluate the efficacy and safety of NIR178 in combination with PDR001 in multiple solid tumors and diffuse large B-cell lymphoma (DLBCL) and further explore schedule variations of NIR178 to optimize immune activation through inhibition of A2aR. Dose escalation will be based on ascending weight-based dose levels (DLs) of dostarlimab and will continue until the maximum tolerated dose (MTD) is reached or may be stopped at any dose level up to the highest dose of 20 milligrams per kilograms (mg / kg) based on emerging safety and PK / PDy data. Location: 6 locations, This phase III trial studies how well either FOLFIRI (leucovorin, fluorouracil, and irinotecan), active surveillance, nivolumab, or encorafenib, binimetinib, and cetuximab work in decreasing recurrence (chance of the cancer coming back) in patients with stage III colorectal cancer who are ctDNA positive. Location: 28 locations, This is an open-label, multicenter, multinational, Phase 2 basket study exploring the efficacy and safety of neratinib as monotherapy or in combination with other therapies in participants with HER (EGFR, HER2) mutation-positive solid tumors. Finding ctDNA in the blood means that there are very likely small amounts of cancer remaining after surgery that may not be detectable using other tests, such as medical imaging. The COBRA trial, which opened to accrual in December 2019, is expected to enroll over 1,400 patients who have resected stage IIA colon cancer that is considered low-risk and would not … Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09 / 19 / 2018) 29. Location: 23 locations, This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1 / 2 / 3, ROS1, or ALK gene fusion. Eligible patients will be assigned to one of several treatment arms. Adenoid cystic carcinoma (closed to accrual 02 / 06 / 2018) 35. ... and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. Bevacizumab is a monoclonal antibody that binds to vascular endothelial growth factor (VEGF). Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10 / 17 / 2018) 7. 2009;27:3109-3116. Chemotherapy drugs, such as leucovorin calcium, fluorouracil, oxaliplatin, and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Drugs used in chemotherapy, such as irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. During the Phase 1 dose escalation portion of the trial, NKTR-262 will be combined with systemic administration of bempegaldesleukin. Giving trastuzumab and pertuzumab may work better compared to cetuximab and irinotecan hydrochloride in treating patients with colorectal cancer. Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. Giving combination chemotherapy with atezolizumab may work better than combination chemotherapy alone in treating patients with colon cancer. Nowadays, it is the world's fourth most deadly cancer with almost 900 000 deaths annually. ctDNA are small pieces of genetic materials (DNA) that are shed by tumors into the blood. All trials on the list are supported by NCI.. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Location: 741 locations, This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. The study is composed of a safety run-in and an exploratory part. 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